Pesquisa | BVS Violência e Saúde

1.

Fibroblasts in cancer: Unity in heterogeneity.

Chhabra, Yash; Weeraratna, Ashani T.

Cell ; 186(8): 1580-1609, 2023 04 13.

Artigo em Inglês | MEDLINE | ID: mdl-37059066

2.

Stromal changes in the aged lung induce an emergence from melanoma dormancy.

Fane, Mitchell E; Chhabra, Yash; Alicea, Gretchen M; Maranto, Devon A; Douglass, Stephen M; Webster, Marie R; Rebecca, Vito W; Marino, Gloria E; Almeida, Filipe; Ecker, Brett L; Zabransky, Daniel J; Hüser, Laura; Beer, Thomas; Tang, Hsin-Yao; Kossenkov, Andrew; Herlyn, Meenhard; Speicher, David W; Xu, Wei; Xu, Xiaowei; Jaffee, Elizabeth M; Aguirre-Ghiso, Julio A; Weeraratna, Ashani T.

Nature ; 606(7913): 396-405, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35650435

3.

Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2-Bl/HLA-G.

Ishikawa, Mayumi; Brooks, Andrew J; Fernández-Rojo, Manuel A; Medina, Johan; Chhabra, Yash; Minami, Shiro; Tunny, Kathryn A; Parton, Robert G; Vivian, Julian P; Rossjohn, Jamie; Chikani, Viral; Ramm, Grant A; Ho, Ken K Y; Waters, Michael J.

Hepatology ; 73(2): 759-775, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-32342533

4.

Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning.

Bridgford, Jessica L; Lee, Su Min; Lee, Christine M M; Guglielmelli, Paola; Rumi, Elisa; Pietra, Daniela; Wilcox, Stephen; Chhabra, Yash; Rubin, Alan F; Cazzola, Mario; Vannucchi, Alessandro M; Brooks, Andrew J; Call, Matthew E; Call, Melissa J.

Blood ; 135(4): 287-292, 2020 01 23.

Artigo em Inglês | MEDLINE | ID: mdl-31697803

5.

Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity.

Chhabra, Yash; Nelson, Caroline N; Plescher, Monika; Barclay, Johanna L; Smith, Aaron G; Andrikopoulos, Sof; Mangiafico, Salvatore; Waxman, David J; Brooks, Andrew J; Waters, Michael J.

FASEB J ; 33(5): 6412-6430, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30779881

6.

Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma.

Marino-Bravante, Gloria E; Carey, Alexis E; Hüser, Laura; Dixit, Agrani; Wang, Vania; Kaur, Amanpreet; Liu, Ying; Ding, Supeng; Schnellmann, Rahel; Gerecht, Sharon; Gu, Luo; Eisinger-Mathason, T S Karin; Chhabra, Yash; Weeraratna, Ashani T.

Nat Aging ; 4(3): 350-363, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38472454

7.

Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression.

Zabransky, Daniel J; Chhabra, Yash; Fane, Mitchell E; Kartalia, Emma; Leatherman, James M; Hüser, Laura; Zimmerman, Jacquelyn W; Delitto, Daniel; Han, Song; Armstrong, Todd D; Charmsaz, Soren; Guinn, Samantha; Pramod, Sneha; Thompson, Elizabeth D; Hughes, Steven J; O'Connell, Jennifer; Egan, Josephine M; Jaffee, Elizabeth M; Weeraratna, Ashani T.

Cancer Res ; 84(8): 1221-1236, 2024 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-38330147

8.

Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation.

Chhabra, Yash; Seiffert, Pernille; Gormal, Rachel S; Vullings, Manon; Lee, Christine Mei Mei; Wallis, Tristan P; Dehkhoda, Farhad; Indrakumar, Sowmya; Jacobsen, Nina L; Lindorff-Larsen, Kresten; Durisic, Nela; Waters, Michael J; Meunier, Frédéric A; Kragelund, Birthe B; Brooks, Andrew J.

Cell Rep ; 42(5): 112490, 2023 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-37163374

9.

Differential response to sustained stimulation by hCG & LH on goat ovarian granulosa cells.

Gupta, Chanchal; Chapekar, Trimbak; Chhabra, Yash; Singh, Prashant; Sinha, Subrata; Luthra, Kalpana.

Indian J Med Res ; 135: 331-40, 2012 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-22561619

10.

Reciprocal Regulation of BRN2 and NOTCH1/2 Signaling Synergistically Drives Melanoma Cell Migration and Invasion.

Fane, Mitchell E; Chhabra, Yash; Spoerri, Loredana; Simmons, Jacinta L; Ludwig, Raquelle; Bonvin, Elise; Goding, Colin R; Sturm, Richard A; Boyle, Glen M; Haass, Nikolas K; Piper, Michael; Smith, Aaron G.

J Invest Dermatol ; 142(7): 1845-1857, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-34958806

11.

GHR signalling: Receptor activation and degradation mechanisms.

Chhabra, Yash; Lee, Christine M M; Müller, Alexandra Franziska; Brooks, Andrew J.

Mol Cell Endocrinol ; 520: 111075, 2021 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-33181235

12.

Myeloid-Derived Suppressor Cells Are a Major Source of Wnt5A in the Melanoma Microenvironment and Depend on Wnt5A for Full Suppressive Activity.

Douglass, Stephen M; Fane, Mitchell E; Sanseviero, Emilio; Ecker, Brett L; Kugel, Curtis H; Behera, Reeti; Kumar, Vinit; Tcyganov, Evgenii N; Yin, Xiangfan; Liu, Qin; Chhabra, Yash; Alicea, Gretchen M; Kuruvilla, Rejji; Gabrilovich, Dmitry I; Weeraratna, Ashani T.

Cancer Res ; 81(3): 658-670, 2021 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-33262126

13.

sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients.

Fane, Mitchell E; Ecker, Brett L; Kaur, Amanpreet; Marino, Gloria E; Alicea, Gretchen M; Douglass, Stephen M; Chhabra, Yash; Webster, Marie R; Marshall, Andrea; Colling, Richard; Espinosa, Olivia; Coupe, Nicholas; Maroo, Neera; Campo, Leticia; Middleton, Mark R; Corrie, Pippa; Xu, Xiaowei; Karakousis, Giorgos C; Weeraratna, Ashani T.

Clin Cancer Res ; 26(21): 5709-5719, 2020 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-33097493

14.

BRN2, a POUerful driver of melanoma phenotype switching and metastasis.

Fane, Mitchell E; Chhabra, Yash; Smith, Aaron G; Sturm, Richard A.

Pigment Cell Melanoma Res ; 32(1): 9-24, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-29781575

15.

Growth hormone activated STAT5 is required for induction of beige fat in vivo.

Nelson, Caroline N; List, Edward O; Ieremia, Makerita; Constantin, Lena; Chhabra, Yash; Kopchick, John J; Waters, Michael J.

Growth Horm IGF Res ; 42-43: 40-51, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30193158

16.

Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma response in melanocytic cells.

Chhabra, Yash; Yong, Hilary X L; Fane, Mitchell E; Soogrim, Arish; Lim, Wen; Mahiuddin, Dayana Nur; Kim, Reuben S Q; Ashcroft, Melinda; Beatson, Scott A; Ainger, Stephen A; Smit, Darren J; Jagirdar, Kasturee; Walker, Graeme J; Sturm, Richard A; Smith, Aaron G.

Pigment Cell Melanoma Res ; 31(1): 51-63, 2018 01.

Artigo em Inglês | MEDLINE | ID: mdl-28755520

17.

Correction: sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients.

Fane, Mitchell E; Ecker, Brett L; Kaur, Amanpreet; Marino, Gloria E; Alicea, Gretchen M; Douglass, Stephen M; Chhabra, Yash; Webster, Marie R; Marshall, Andrea; Colling, Richard; Espinosa, Olivia; Coupe, Nicholas; Maroo, Neera; Campo, Leticia; Middleton, Mark R; Corrie, Pippa; Xu, Xiaowei; Karakousis, Giorgos C; Weeraratna, Ashani T.

Clin Cancer Res ; 29(10): 2012, 2023 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-37183634

18.

NR4A2 Promotes DNA Double-strand Break Repair Upon Exposure to UVR.

Yin, Kelvin; Chhabra, Yash; Tropée, Romain; Lim, Yi Chieh; Fane, Mitchell; Dray, Eloise; Sturm, Richard A; Smith, Aaron G.

Mol Cancer Res ; 15(9): 1184-1196, 2017 09.

Artigo em Inglês | MEDLINE | ID: mdl-28607006

19.

CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis.

Iyer, Swati; Chhabra, Yash; Harvey, Tracey J; Wang, Richard; Chiu, Han Sheng; Smith, A G; Thomas, Walter G; Pennisi, David J; Piper, Michael.

J Mol Histol ; 48(1): 53-61, 2017 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-27803996

20.

NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF.

Fane, Mitchell E; Chhabra, Yash; Hollingsworth, David E J; Simmons, Jacinta L; Spoerri, Loredana; Oh, Tae Gyu; Chauhan, Jagat; Chin, Toby; Harris, Lachlan; Harvey, Tracey J; Muscat, George E O; Goding, Colin R; Sturm, Richard A; Haass, Nikolas K; Boyle, Glen M; Piper, Michael; Smith, Aaron G.

EBioMedicine ; 16: 63-75, 2017 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-28119061

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